Margaret's father Dred had remarried by 1810, with Margaret and sister Rhoda living with their maternal grandmother. In 1820 they were living with Dred again, along with two stepbrothers and two stepsisters all born after 1810. Much of the family migrated to Kentucky in the 1820s. They're mentioned in their well-to-do uncle Thomas Webb's will.
Peggy Shaffer was guessing this is the Margaret Webb who married Thomas Middleton because the dates are about right.
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